WDR73 is a WD repeat-containing protein that functions as a critical assembly factor for the Integrator complex's RNA cleavage module. Specifically, WDR73 associates with INTS9 and INTS11 in the cytoplasm, stabilizing their heterodimer and blocking the INTS11 active site until BRAT1 joins the complex to facilitate nuclear import 1. This role is essential for Integrator's dual functions in transcription regulation—attenuating coding gene expression via premature termination and processing non-coding RNAs 1. WDR73 also stabilizes PIP4K2C through the autophagy-lysosomal pathway, thereby supporting focal adhesion formation critical for podocyte integrity 2. WDR73 mutations cause Galloway-Mowat syndrome (GMS), an autosomal recessive disorder characterized by early-onset steroid-resistant nephrotic syndrome, microcephaly, and severe neurological impairment 34. Disease manifestations include infantile cerebellar atrophy, intellectual disability, retinopathy, basal ganglia degeneration, and variable kidney involvement 4. WDR73 deficiency disrupts pathways regulating uridylate-rich small nuclear RNA processing, transcriptional responses, and cell cycle control—processes critical for maintaining post-mitotic cells like neurons and podocytes 5. The syndrome's neuro-renal phenotype reflects WDR73's expression in both brain and kidney tissues and its role in microtubule organization and cell architecture 3. Loss-of-function mutations impair cell viability and nuclear morphology, explaining the degenerative neurological and renal features of GMS 3.