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0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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WFDC11
WAP four-disulfide core domain 11
Chromosome 20 Β· 20q13.12
NCBI Gene: 259239Ensembl: ENSG00000180083.11HGNC: HGNC:20478UniProt: Q8NEX6
10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
serine-type endopeptidase inhibitor activityantibacterial humoral responseinnate immune responseGO:0005615retinitis pigmentosaage-related macular degenerationX-linked retinal dysplasiaAbnormality of the genital system
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

WAP four-disulfide core domain 11

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
retinitis pigmentosaOpen Targets
0.10Weak
age-related macular degenerationOpen Targets
0.09Suggestive
X-linked retinal dysplasiaOpen Targets
0.08Suggestive
Abnormality of the genital systemOpen Targets
0.08Suggestive
Progressive cone dystrophyOpen Targets
0.07Suggestive
Familial exudative vitreoretinopathyOpen Targets
0.07Suggestive
choroidal dystrophy, central areolar, 1Open Targets
0.06Suggestive
severe early-childhood-onset retinal dystrophyOpen Targets
0.06Suggestive
Stargardt diseaseOpen Targets
0.06Suggestive
reticular dystrophy of the retinal pigment epitheliumOpen Targets
0.06Suggestive
age related macular degeneration 11Open Targets
0.06Suggestive
age related macular degeneration 2Open Targets
0.06Suggestive
age related macular degeneration 4Open Targets
0.06Suggestive
age related macular degeneration 6Open Targets
0.06Suggestive
age related macular degeneration 7Open Targets
0.06Suggestive
coloboma of maculaOpen Targets
0.05Suggestive
Familial drusenOpen Targets
0.05Suggestive
X-linked retinoschisisOpen Targets
0.05Suggestive
Stargardt disease 4Open Targets
0.05Suggestive
coloboma of optic nerveOpen Targets
0.05Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
WFDC3Shared pathway100%WFDC10AShared pathway100%WFDC5Shared pathway100%WFDC10BShared pathway100%WFDC9Shared pathway100%WFDC13Protein interaction83%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
0%
Ovary
0%
Heart
0%
Liver
0%
Lung
0%
Gene Interaction Network
Click a node to explore
WFDC11WFDC3WFDC10AWFDC5WFDC10BWFDC9WFDC13
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q8NEX6
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.44LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.83 [0.50–1.44]
RankingsWhere WFDC11 stands among ~20K protein-coding genes
  • #17,220of 20,598
    Most Researched10
  • #14,769of 17,882
    Most Constrained (LOEUF)1.44
Genes detectedWFDC11
Sources retrieved0 papers
Response timeβ€”