ZBTB10 (zinc finger and BTB domain containing 10) is a transcriptional repressor that functions as a sequence-specific DNA-binding protein with dual roles in telomeric biology and tumor suppression. ZBTB10 contains tandem C2H2 zinc fingers that specifically recognize telomeric variant repeat sequences TTGGGG 1, and co-localizes with telomeres in ALT cells where it interacts with TRF2/RAP1 2, suggesting a role in alternative telomere lengthening maintenance. In cancer contexts, ZBTB10 acts as a tumor suppressor. Downregulation of ZBTB10 promotes neuroendocrine differentiation in androgen-deprivation therapy-resistant prostate cancer by derepressing pyruvate kinase L/R (PKLR), enhancing glycolytic metabolism 3. In gastric cancer, ZBTB10 overexpression suppresses progression by activating ARRDC3, which promotes ITGB4 ubiquitination and degradation, thereby inactivating PI3K/AKT signaling 4. Higher ZBTB10 expression correlates with poor prognosis in gastric adenocarcinoma despite its tumor-suppressive functions, potentially through immune microenvironment modulation 5. ZBTB10 also acts downstream of betulinic acid treatment, where increased ZBTB10 expression represses Sp transcription factors and mediates anti-cancer effects in breast cancer 6. Genetically, ZBTB10 variants associate with late-onset myasthenia gravis susceptibility 7, indicating immunological relevance beyond cancer biology.