ZBTB34 (zinc finger and BTB domain containing 34) is a transcriptional repressor protein with a BTB/POZ domain at its N-terminus 1. The protein localizes to the nucleus via a monopartite nuclear localization signal (NLS) spanning residues 320-329, with nuclear import mediated by importin α1, α3, α4, and β1 2. ZBTB34 functions as a miRNA-regulated transcriptional repressor that downregulates specificity protein (Sp) transcription factors, including Sp1, Sp3, and Sp4 34. Its expression is regulated by microRNAs: miR-125b-5p in hepatocellular carcinoma 2 and miR-4319 in colorectal cancer 5. In cancer biology, ZBTB34 expression is increased through ROS-inducing therapeutic agents, which suppress oncogenic miRNAs and activate this repressor as part of anti-cancer pathways 346. ZBTB34 has been identified as a hepatocellular carcinoma-associated protein with elevated expression in liver cancer tissues 2 and ranks among top target-mRNAs in Kaposi's sarcoma networks 7. These findings suggest ZBTB34 serves as a tumor suppressor through transcriptional repression of oncogenic transcription factors, making it a potential therapeutic target for cancer treatment.