Based on limited published evidence, ZBTB45 is a zinc finger and BTB domain-containing protein likely involved in transcriptional regulation through RNA polymerase II-mediated repression and sequence-specific DNA binding. In the central nervous system, it may participate in glial cell differentiation. GO annotations indicate roles in immune system regulation and cytokine production control. ZBTB45 DNA methylation patterns have been identified as potential epigenetic biomarkers associated with metabolic health status transitions 1, though functional validation remains needed.