ZC3HC1 (zinc finger C3HC-type containing 1) is a nuclear basket protein essential for nuclear pore complex (NPC) organization and function. Structurally, ZC3HC1 contains an evolutionarily conserved bimodular nuclear basket-interaction domain (NuBaID) comprising two integrated zf-C3HC and Rsm1 modules 1. Its primary function involves anchoring to the nuclear basket through TPR-dependent binding, after which it can recruit additional TPR polypeptides to stabilize basket structure 2. However, ZC3HC1 possesses distinct functions beyond TPR stabilization; while TPR localization at nuclear pores remains intact following ZC3HC1 depletion, knockdown of ZC3HC1 and TPR produce partially overlapping but distinct transcriptional consequences 3. ZC3HC1 participates in a regulatory axis with HROB and CCNB1 that controls cell cycle progression through K27-linked ubiquitination of CCNB1, suppressing G2-to-M transition and cell proliferation 4. Clinically, ZC3HC1 genetic variants associate with multiple cardiovascular and cerebrovascular disease risks: the rs11556924 polymorphism correlates with coronary artery disease, large artery ischemic stroke, and hypertension susceptibility 567. Additionally, ZC3HC1 emerges as a potential diagnostic and therapeutic target in cerebral infarction through miRNA-regulated networks 8.