ZCCHC12 (zinc finger CCHC-type containing 12) functions as a transcriptional coactivator with roles in multiple signaling pathways and cancer progression. The protein localizes to the nucleus through a novel nuclear localization signal and is highly expressed in brain tissue, specifically in neuroepithelium of forebrain, midbrain, and diencephalon regions during embryonic development 1. ZCCHC12 enhances transcriptional activities of activator protein 1 (AP-1) and cAMP response element binding protein (CREB) as a coactivator 1. In cancer contexts, ZCCHC12 acts as an oncogene, being significantly upregulated in papillary thyroid cancer (PTC) where it correlates with lymph node metastasis and promotes cell colony formation, migration, and invasion 2. The protein also promotes osteosarcoma progression through PI3K/AKT pathway activation, enhancing proliferation, migration, and epithelial-mesenchymal transition while inducing apoptosis and cell cycle arrest when downregulated 3. In PTC, ZCCHC12+ tumor cells interact with CD36+ proinflammatory macrophages, contributing to tumor progression and recurrence 4. Additionally, ZCCHC12 expression is regulated by competing endogenous RNA networks involving LINC00475 and miR-376c-3p in thyroid cancer 5. The gene has also been incorporated into machine learning-based prognostic models for hepatoblastoma 6.