ZDHHC23 is a palmitoyltransferase that catalyzes S-palmitoylation of diverse protein substrates, regulating their membrane localization and function. The enzyme mediates palmitoylation of KCNMA1 to control BK channel localization to the plasma membrane 1, and in spinal astrocytes, palmitoylates GFAP to enhance inflammatory factor secretion and pain signaling 2. ZDHHC23 also palmitoylates PHF2, promoting its ubiquitin-dependent degradation and consequently activating lipogenic pathways in hepatocellular carcinoma 3, and mediates T-bet palmitoylation to regulate Th1 cell differentiation in gastric cancer 4. Pan-cancer analysis identifies ZDHHC23 among palmitoylation-related genes dysregulated by oncogenic Myc signaling, with contributions to mTOR signaling, DNA repair, and immune pathways that influence tumorigenesis and immunotherapy response 5. In glioblastoma, ZDHHC23 competes with ZDHHC18 for interaction with the E3 ligase RNF144A to regulate BMI1 polyubiquitination, controlling glioma stem cell plasticity 6. ZDHHC23 expression correlates with esophageal cancer radiosensitivity through miRNA-mRNA regulatory networks 7 and associates with white blood cell counts in acute lymphoblastic leukemia 8, suggesting broader roles in cancer biology and hematologic malignancies.