ZFP1 is a zinc finger protein functioning as a DNA-binding transcription factor with RNA polymerase II-specific regulatory activity 1. The protein contains seven zinc fingers and two helix-turn-helix motifs characteristic of transcriptional regulators 2, with ubiquitous expression across tissues and developmental stages 2. In cancer biology, ZFP1 overexpression correlates with poor prognosis in gastric cancer, associating with advanced tumor stage and histological grade 1. Elevated ZFP1 expression correlates with reduced overall survival, disease-specific survival, and progression-free intervals 1. ZFP1 modulates anti-tumor immunity by positively correlating with effector central memory T cells and T helper cells while negatively correlating with Th17 cells and NK CD56bright cells 1. ZFP1 interacts with TERF2, a telomere integrity regulator implicated in multiple cancers 3. Beyond malignancy, ZFP1 is localized to chromosome 16, a region subject to alterations in acute myeloid leukemia 4. In C. elegans, zfp-1 is required for RNAi effectiveness and vulval lineage development 5. ZFP1 mapping to chromosome 16 is conserved across species, positioned between regulatory genes in a functionally integrated cluster 6. These findings establish ZFP1 as a multi-functional transcriptional regulator with significant roles in cancer progression and immune response.