ZGPAT (zinc finger CCCH-type and G-patch domain containing) is a transcriptional regulatory protein that functions as a transcriptional repressor through chr20-mediated mechanisms. The protein contains zinc finger CCCH-type and G-patch domains and localizes to the nucleus and nucleoplasm where it binds to chr20 and regulates RNA polymerase II-mediated transcription [UniProt]. ZGPAT acts as a transcriptional repressor that can be sequestered by long non-coding RNAs, thereby relieving its repressive effects on target genes. Specifically, PAXIP1-AS1 lncRNA upregulates CNTNAP3 expression by sequestering ZGPAT, preventing its transcriptional repression 1. The gene has clinical relevance in multiple disease contexts. Genetic variants in the TNFRSF6B-ZGPAT locus show significant associations with atopic dermatitis susceptibility, with SNP rs6010620 demonstrating interaction effects with other genetic variants 23. Additionally, DNA methylation at a CpG site within ZGPAT (cg14083603) shows sex-specific longitudinal associations with lung function, suggesting epigenetic regulation of this locus may influence respiratory phenotypes 4. ZGPAT has also been identified as a CAR T cell integration site in T cell lymphoma cases 5.