ZMYM3 is an X-linked zinc finger transcriptional coregulator that functions as a component of the KDM1A-RCOR1 chrX-modifying complex 1. It plays roles in transcriptional regulation and chrX remodeling, with expression across human tissues 1. In cancer biology, ZMYM3 functions as a putative tumor suppressor gene in pan-cancer contexts 2, though it paradoxically promotes hepatocellular carcinoma metastasis by upregulating CTTN and inducing invadopodia formation 3. Clinically, ZMYM3 is associated with X-linked intellectual developmental disorder 112 1, with 27 documented individuals harboring protein-altering variants exhibiting developmental delay, intellectual disability, and behavioral abnormalities 1. Recurrent missense variants affecting conserved residues (Arg441 and Arg1294Cys) demonstrate reduced genomic occupancy, indicating hypomorphic effects 1. Additionally, ZMYM3 variants appear implicated in male infertility through altered spermatogenesis 45, and the exceptionally long GA-STR in ZMYM3's 5' UTR shows architectural skewing in late-onset neurocognitive disorder patients 6. ZMYM3 mutations also emerge as recurrent driver alterations in chrX lymphocytic leukemia 7.