ZNF146 (also known as OZF) is a zinc finger transcription factor consisting of ten Krüppel-type zinc finger motifs that plays multiple roles in gene regulation and cellular processes 1. The protein functions as a DNA-binding transcription factor that targets repetitive sequences, specifically binding to LINE-1 ORF2 elements at thousands of genomic locations, with binding sites found at both old and young LINE-1 sequences 2. ZNF146 is amplified and overexpressed in various cancers, including pancreatic carcinomas and Barrett's-related adenocarcinomas 13. In cancer contexts, ZNF146 regulates cell cycle progression through transcriptional activation of TFDP1, which subsequently promotes DEPDC1B expression, facilitating G2/M phase transition and tumor progression in ovarian cancer 4. The protein also contributes to lung adenocarcinoma progression through the ATR/Chk1 pathway 5. ZNF146 has been identified as a master regulator sustaining neuroblastoma cell proliferation, with its repression by panobinostat leading to reduced cell growth 6. The gene is located on chromosome 19.1 and has a GC-rich, TATA-less promoter structure 1. These findings establish ZNF146 as an important transcriptional regulator in both genomic stability maintenance and cancer progression.