ZNF148 is a zinc finger transcription factor that functions as both a transcriptional repressor and activator depending on cellular context. It binds to G-rich box sequences in gene enhancer regions to regulate transcription 1. In endothelial cells, ZNF148 interacts with ATG7 to modulate STAT1 expression, which subsequently suppresses HIF1A transcription and impairs ischemia-induced angiogenesis 1. ZNF148 also serves as a transcriptional regulator of TERT promoter mutations, activating telomerase expression in cancer cells 2. In head and neck squamous cell carcinoma, ZNF148 cooperates with p63 to enhance CCND1 expression through eRNA regulation, promoting tumor cell proliferation 3. Conversely, in breast cancer, ZNF148 acts as a tumor suppressor by repressing ID1/ID3 stemness factors 4. In esophageal squamous cell carcinoma, ZNF148 is targeted by the miR-143-3p/circRNA axis, with downregulation promoting cancer progression 5. Clinically, ZNF148 mutations cause neurodevelopmental disorders, with pathogenic variants producing ZNF148-related neurodevelopmental disorder characterized by global developmental delay, growth retardation, microcephaly, and facial dysmorphism 67. ZNF148 mutations are also emerging as potential diagnostic markers for thyroid malignancy classification 8.