ZNF236 is a Kruppel-like zinc-finger transcription factor that functions as a glucose-regulated gene involved in transcriptional regulation 1. The protein contains 25-30 C2H2 zinc-finger motifs and is ubiquitously expressed across human tissues, with highest levels in skeletal muscle and brain 1. At the molecular level, ZNF236 exhibits DNA-binding transcription factor activity specific to RNA polymerase II cis-regulatory regions and participates in cellular responses to glucose stimulation 2. Genome-scale functional genomics studies identified ZNF236 as a regulator of ribosome biogenesis 2. Additionally, ZNF236 was identified as a host factor involved in influenza A virus replication 3. A circular RNA form (circ-ZNF236) regulates stem cell differentiation through a miR-218-5p/LGR4 axis and autophagy activation 4. Clinically, ZNF236 shows relevance to cleft palate, with SNP variants associated with increased risk in the presence of maternal smoking 5. ZNF236 was identified as a candidate gene for diabetic nephropathy due to glucose-regulated expression in mesangial cells and mapping near the IDDM6 locus 1; however, sequencing studies found no mutations conferring susceptibility 6. Candidate variants in ZNF236 have also been identified in childhood disintegrative disorder, a neurodevelopmental condition 7.