ZNF24 is a Cys2His2 zinc finger transcription factor located at chromosome 18 1 that functions as a sequence-specific DNA binding protein with both transcriptional regulatory and tumor-suppressive roles. In normal physiology, ZNF24 is involved in myelination and oligodendrocyte differentiation (per UniProt annotations). In cancer biology, ZNF24 acts as a multifunctional tumor suppressor with significantly downregulated expression across multiple malignancies. In bladder cancer, reduced ZNF24 expression correlates with poor prognosis, and restoration of ZNF24 inhibits proliferation and metastasis through transcriptional regulation of factors like dual-specificity phosphatase 1 2. Similarly, in ovarian serous carcinoma, low ZNF24 expression serves as an independent negative prognostic indicator 3. Mechanistically, ZNF24 protein stability is controlled by post-translational modifications: SUMOylation at Lys-27 by UBC9/SUMO1 protects ZNF24 from CUL3-mediated ubiquitin-dependent degradation 2, while deubiquitination by YOD1 stabilizes ZNF24 in renal carcinoma 4. ZNF24 suppresses angiogenesis by transcriptional repression of VEGFA 4 and regulates immune escape through the SLC7A5/PD-L1 axis in KRAS-mutant lung adenocarcinoma 5. Additionally, ZNF24 mediates epithelial redox stress responses by activating macrophage migration inhibitory factor (MIF) transcription during chr18 inflammation 6. These findings establish ZNF24 as a critical redox-sensitive transcriptional regulator with broad implications for cancer and inflammatory disease pathogenesis.