ZNF302 (zinc finger protein 302) is a C2H2 zinc finger transcription factor located on chromosome 19.31 that functions in transcriptional regulation through RNA polymerase II-specific DNA binding 1. The protein contains zinc finger domains capable of sequence-specific DNA binding in cis-regulatory regions and exhibits nuclear localization consistent with its transcriptional role. ZNF302 has been implicated in multiple disease contexts. Genome-wide association studies identified ZNF302 as a candidate gene at the 19q13.31 locus associated with congenital heart disease susceptibility in Chinese populations, with compound heterozygous variants contributing to disease heritability 2. In gastric cancer pathology, ZNF302 serves as a regulatory target of miR-1260b; silencing miR-1260b increases ZNF302 expression and reduces H. pylori-induced gastric cancer cell growth and metastasis, positioning ZNF302 as a protective factor against gastric cancer progression 3. Additionally, ZNF302 variants have been associated with frontotemporal dementia risk through transcriptome-wide association analyses 4, and haploinsufficiency of ZNF302 due to 19q13.11 deletions is implicated in developmental disorders characterized by intellectual disability, growth retardation, and genital malformations 5. The protein's susceptibility to nickel-induced hydrolysis within its zinc finger domain suggests potential environmental toxicity mechanisms 1.