ZNF320 is a Krüppel-like zinc finger protein that functions as a transcriptional regulator 1. As a member of the zinc finger gene family, ZNF320 possesses DNA-binding transcription factor activity and is localized to the nucleus where it regulates transcription by RNA polymerase II. The gene maps to chromosome 19.3-13.4, a region frequently showing loss of heterozygosity in glial tumors 1. Mechanistically, ZNF320 appears involved in multiple cellular processes including cell cycle regulation and immune modulation 2. Recent studies identify ZNF320 as a hub gene in gene co-expression networks associated with microsatellite instability in colorectal cancer 3, and as a hypomethylated prognostic biomarker in hepatocellular carcinoma 2. Clinically, ZNF320 expression correlates with tumor-infiltrating immune cell abundance—including B cells, CD8+ T cells, macrophages, and dendritic cells—in HCC 2. Polymorphisms in ZNF320 have been associated with variation in blood biomarker levels relevant to Alzheimer's disease susceptibility 4. These findings suggest ZNF320 functions at the intersection of transcriptional regulation, immune response, and cell cycle control, with implications for cancer prognosis and potentially neurological disease.