ZNF350 is a transcriptional repressor protein that functions as a BRCA1-interacting factor in tumor suppression pathways 1. The protein binds to specific DNA sequences and mediates BRCA1-induced transcriptional repression of target genes, particularly GADD45α, which is involved in DNA damage repair 21. ZNF350 belongs to the KRAB-ZFP family, characterized by an N-terminal KRAB domain and C-terminal zinc finger arrays that enable sequence-specific DNA binding 3. Recent research has identified ZNF350's role in regulating ferroptosis, where it transcriptionally inhibits NCOA4, and its degradation by HECW1 ubiquitination leads to enhanced iron accumulation and lipid peroxidation in glioma cells 4. The gene shows significant clinical relevance in multiple diseases. Genetic variants in ZNF350, particularly missense mutations like L66P and S501R, are associated with altered breast cancer susceptibility in various populations, potentially by weakening the protein's transcriptional repression capabilities 156. Additionally, ZNF350 has been identified as a potential biomarker for osteoporosis, with elevated expression levels observed in osteoporotic samples 7. Interestingly, ZNF350 genes on chromosome 19 serve as preferential HIV-1 integration sites in elite controllers, contributing to viral reservoir silencing 8.