ZNF385B is a zinc finger protein located at chromosome 2.3 that functions as a modulator of p53-mediated apoptosis with tissue-specific roles in development and cancer regulation. The protein is characteristically expressed in germinal center B cells and brain tissue 12. ZNF385B contains multiple zinc finger domains and directly binds p53, regulating its transactivation to control apoptotic pathways 1. The longest transcript variant (four zinc finger domains) promotes apoptosis through upregulation of pro-apoptotic factors FAS/CD95 and PERP and caspase activation, while shorter isoforms with three zinc finger domains can inhibit apoptosis, indicating isoform-dependent functional duality 1. ZNF385B also serves as a direct transcriptional target of ΔNp63α and regulates cell junction genes involved in epithelial homeostasis 3. Clinically, ZNF385B is significantly downregulated in moderately to poorly differentiated serous ovarian carcinomas and correlates with improved overall survival 4. Genomic disruptions of ZNF385B through deletions associate with neurodevelopmental abnormalities including epilepsy, intellectual disability, and skeletal anomalies 25. Additionally, ZNF385B harbors miR-1258 within its first intron; epigenetic silencing of this microRNA in multiple myeloma promotes tumor progression through PDL1 upregulation 6. Polymorphisms near ZNF385B have been identified as novel genetic risk loci for age-related macular degeneration 7.