ZNF570 is a zinc finger transcription factor that functions as a DNA-binding protein involved in RNA polymerase II-mediated transcriptional regulation [GO Annotations]. The gene is located on chromosome 19 and exhibits significant clinical relevance in cancer biology. In oral squamous cell carcinoma (OSCC), ZNF570 expression is associated with patient survival outcomes, with expression levels serving as a component of prognostic signatures that predict overall survival 1. ZNF570 expression is significantly correlated with DNA methylation patterns at its regulatory loci, contributing to integrated prognostic models combining methylation, gene expression, and clinical data 1. In hormone receptor-positive breast cancer, ZNF570 is overexpressed and functions as an independent prognostic indicator linked to poorer patient outcomes 2. Mechanistically, ZNF570 promotes tamoxifen resistance by enhancing estrogen receptor alpha (ERα) activity and suppressing ferroptosis, a form of regulated cell death 2. ZNF570 knockout reverses tamoxifen resistance by activating ferroptosis through downregulation of glutathione peroxidase 4 (GPX4) and cystine/glutamate transporter (XCT), coupled with p53 upregulation and increased reactive oxygen species accumulation 2. Additionally, ZNF570 localizes to chromosome 19.12 and its expression is regulated by nuclear lamina organization through Lamin B2-mediated maintenance of nuclear architecture 3.