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GeneE
2 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
ZNF572
zinc finger protein 572
Chromosome 8 Β· 8q24.13
NCBI Gene: 137209Ensembl: ENSG00000180938.7HGNC: HGNC:26758UniProt: Q7Z3I7
14PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingidentical protein bindingnucleusregulation of cytokine productionprostate carcinomaalopeciaprostate cancerbenign neoplasm of eye
✦AI Summary

Based on limited published evidence, ZNF572 is a zinc finger protein predicted to function in transcriptional regulation. UniProt annotations indicate DNA-binding transcription repressor activity specific to RNA polymerase II, with roles in negative regulation of transcription and immune system processes. ZNF572 localizes to the nucleus and nucleoplasm. Genome-wide association studies have identified genetic variants near ZNF572 associated with postpartum depression 1 and altered expression in amniotic fluid linked to preterm birth risk 2, suggesting involvement in perinatal health outcomes, though mechanistic details remain unclear.

Sources cited
1
Genetic variant rs188907279 near ZNF572 was significantly associated with postpartum depression in GWAS of Japanese perinatal women
PMID: 39287932
2
ZNF572 expression was upregulated in amniotic fluid from preterm birth cases and increased under oxidative stress and infection conditions in trophoblast cells
PMID: 35361790
⚠Limited data available β€” This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
prostate carcinomaOpen Targets
0.41Moderate
alopeciaOpen Targets
0.29Weak
prostate cancerOpen Targets
0.27Weak
benign neoplasm of eyeOpen Targets
0.25Weak
cardiomyopathyOpen Targets
0.24Weak
atrial fibrillationOpen Targets
0.21Weak
joint diseaseOpen Targets
0.21Weak
hypertrophic cardiomyopathyOpen Targets
0.20Weak
heart failureOpen Targets
0.19Weak
dilated cardiomyopathyOpen Targets
0.18Weak
exostosisOpen Targets
0.15Weak
Down syndromeOpen Targets
0.04Suggestive
cholelithiasisOpen Targets
0.02Suggestive
cancerOpen Targets
0.01Suggestive
ataxia telangiectasiaOpen Targets
0.00Suggestive
progressive pseudorheumatoid arthropathy of childhoodOpen Targets
0.00Suggestive
Townes-Brocks syndromeOpen Targets
0.00Suggestive
infectionOpen Targets
0.00Suggestive
intrahepatic cholestasisOpen Targets
0.00Suggestive
lung cancerOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
ZBTB14Shared pathway100%ZBTB25Shared pathway100%ZNF131Shared pathway100%ZNF134Shared pathway100%ZBTB39Shared pathway100%ZBTB6Shared pathway100%
Tissue Expression6 tissues
Ovary
100%
Heart
79%
Liver
60%
Brain
60%
Lung
27%
Bone Marrow
15%
Gene Interaction Network
Click a node to explore
ZNF572ZBTB14ZBTB25ZNF131ZNF134ZBTB39ZBTB6
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q7Z3I7
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.52LoF Tolerant
pLIβ“˜
0.21Tolerant
Observed/Expected LoF0.51 [0.21–1.52]
RankingsWhere ZNF572 stands among ~20K protein-coding genes
  • #16,068of 20,598
    Most Researched14
  • #15,253of 17,882
    Most Constrained (LOEUF)1.52
Genes detectedZNF572
Sources retrieved2 papers
Response timeβ€”
πŸ“„ Sources
2
1
Identification of risk loci for postpartum depression in a genome-wide association study.
PMID: 39287932
Psychiatry Clin Neurosci Β· 2024
1.00
2
Identification of a novel gene signature in second-trimester amniotic fluid for the prediction of preterm birth.
PMID: 35361790
Sci Rep Β· 2022
0.50