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GeneE
2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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ZNF615
zinc finger protein 615
Chromosome 19 · 19q13.41
NCBI Gene: 284370Ensembl: ENSG00000197619.15HGNC: HGNC:24740UniProt: B4DH87
10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
transcription cis-regulatory region bindingregulation of transcription by RNA polymerase IInucleussequence-specific DNA bindingneurodegenerative diseaseParkinson diseaseAlzheimer diseasemultiple sclerosis
✦AI Summary

Based on limited published evidence, ZNF615 is a zinc finger protein localized to the nucleus with predicted involvement in transcriptional regulation. GO annotations indicate it functions in regulation of transcription by RNA polymerase II and transcription cis-regulatory region binding. In a genome-wide association study of cattle calving performance, ZNF615 was identified as a candidate gene on chromosome 19 with a highly significant missense variant, though functional impact assessment suggested limited direct effect 1. In diffuse large B-cell lymphoma with TET2 mutations, ZNF615 was identified as a key hypermethylated and downregulated gene 2, suggesting potential involvement in lymphoma pathogenesis.

Sources cited
1
ZNF615 identified as candidate gene on chromosome 18 with missense variant in cattle calving performance GWAS
PMID: 26065883
2
ZNF615 identified as hypermethylated and downregulated key gene in DLBCL with TET2 mutations
PMID: 28731140
⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Alzheimer diseaseOpen Targets
0.27Weak
lysosomal storage diseaseOpen Targets
0.27Weak
multiple sclerosisOpen Targets
0.27Weak
neurodegenerative diseaseOpen Targets
0.27Weak
Parkinson diseaseOpen Targets
0.27Weak
Shwachman-Diamond syndrome 1Open Targets
0.03Suggestive
atypical hemolytic-uremic syndrome with C3 anomalyOpen Targets
0.03Suggestive
hyperuricemic nephropathy, familial juvenile type 4Open Targets
0.03Suggestive
atypical hemolytic-uremic syndrome with I factor anomalyOpen Targets
0.03Suggestive
atypical hemolytic-uremic syndrome with MCP/CD46 anomalyOpen Targets
0.03Suggestive
atypical hemolytic-uremic syndrome with thrombomodulin anomalyOpen Targets
0.03Suggestive
Blackfan-Diamond anemiaOpen Targets
0.03Suggestive
familial juvenile hyperuricemic nephropathy type 1Open Targets
0.03Suggestive
tubulointerstitial kidney disease, autosomal dominant, 2Open Targets
0.03Suggestive
congenital dyserythropoietic anemia type 4Open Targets
0.03Suggestive
Congenital dyserythropoietic anemia type IVOpen Targets
0.03Suggestive
atypical hemolytic-uremic syndrome with B factor anomalyOpen Targets
0.03Suggestive
Thrombocytopenia - absent radiusOpen Targets
0.03Suggestive
thrombocytopenia-absent radius syndromeOpen Targets
0.03Suggestive
Microcephaly - cervical spine fusion anomaliesOpen Targets
0.03Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
ZNF461Protein interaction80%
Tissue Expression6 tissues
Heart
100%
Ovary
96%
Bone Marrow
80%
Brain
71%
Liver
49%
Lung
47%
Gene Interaction Network
Click a node to explore
ZNF615ZNF461
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q8N8J6
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.37LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.83 [0.52–1.37]
RankingsWhere ZNF615 stands among ~20K protein-coding genes
  • #17,240of 20,598
    Most Researched10
  • #14,270of 17,882
    Most Constrained (LOEUF)1.37
Genes detectedZNF615
Sources retrieved2 papers
Response time—
📄 Sources
2
1
Genome-wide association study for calving performance using high-density genotypes in dairy and beef cattle.
PMID: 26065883
Genet Sel Evol · 2015
1.00
2
Integrated analysis of genome‑wide gene expression and DNA methylation microarray of diffuse large B‑cell lymphoma with TET mutations.
PMID: 28731140
Mol Med Rep · 2017
0.50