2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETranscription Factor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
transcription cis-regulatory region bindingregulation of transcription by RNA polymerase IInucleussequence-specific DNA bindingneurodegenerative diseaseParkinson diseaseAlzheimer diseasemultiple sclerosis
Based on limited published evidence, ZNF615 is a zinc finger protein localized to the nucleus with predicted involvement in transcriptional regulation. GO annotations indicate it functions in regulation of transcription by RNA polymerase II and transcription cis-regulatory region binding. In a genome-wide association study of cattle calving performance, ZNF615 was identified as a candidate gene on chromosome 19 with a highly significant missense variant, though functional impact assessment suggested limited direct effect 1. In diffuse large B-cell lymphoma with TET2 mutations, ZNF615 was identified as a key hypermethylated and downregulated gene 2, suggesting potential involvement in lymphoma pathogenesis.
1
ZNF615 identified as candidate gene on chromosome 18 with missense variant in cattle calving performance GWAS
PMID: 260658832
ZNF615 identified as hypermethylated and downregulated key gene in DLBCL with TET2 mutations
PMID: 28731140⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Alzheimer diseaseOpen Targets
lysosomal storage diseaseOpen Targets
multiple sclerosisOpen Targets
neurodegenerative diseaseOpen Targets
Parkinson diseaseOpen Targets
Shwachman-Diamond syndrome 1Open Targets
atypical hemolytic-uremic syndrome with C3 anomalyOpen Targets
hyperuricemic nephropathy, familial juvenile type 4Open Targets
atypical hemolytic-uremic syndrome with I factor anomalyOpen Targets
atypical hemolytic-uremic syndrome with MCP/CD46 anomalyOpen Targets
atypical hemolytic-uremic syndrome with thrombomodulin anomalyOpen Targets
Blackfan-Diamond anemiaOpen Targets
familial juvenile hyperuricemic nephropathy type 1Open Targets
tubulointerstitial kidney disease, autosomal dominant, 2Open Targets
congenital dyserythropoietic anemia type 4Open Targets
Congenital dyserythropoietic anemia type IVOpen Targets
atypical hemolytic-uremic syndrome with B factor anomalyOpen Targets
Thrombocytopenia - absent radiusOpen Targets
thrombocytopenia-absent radius syndromeOpen Targets
Microcephaly - cervical spine fusion anomaliesOpen Targets
No pathogenic variants reported on ClinVar for this gene.