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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
ZNF629
zinc finger protein 629
Chromosome 16 Β· 16p11.2
NCBI Gene: 23361Ensembl: ENSG00000102870.7HGNC: HGNC:29008UniProt: Q9UEG4
50PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Highly ConstrainedTranscription Factor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingnucleoplasmtranscription cis-regulatory region bindingregulation of transcription by RNA polymerase IIneurodegenerative diseaseAlzheimer diseaseParkinson diseasemultiple sclerosis
✦AI Summary

ZNF629 is a zinc finger protein predicted to function in transcriptional regulation. Based on limited published evidence, it localizes to the nucleoplasm and nucleus where it likely binds transcription cis-regulatory regions and regulates RNA polymerase II-dependent transcription through protein-protein interactions. Recent genomic analysis identified ZNF629 as a potential candidate gene associated with spontaneous abortion, though its specific role in this phenotype remains unclear 1.

Sources cited
1
ZNF629 identified as a potential candidate gene associated with spontaneous abortion through CNV analysis and integrative genomic screening
PMID: 38764094
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
neurodegenerative diseaseOpen Targets
0.54Moderate
Alzheimer diseaseOpen Targets
0.39Weak
Parkinson diseaseOpen Targets
0.38Weak
multiple sclerosisOpen Targets
0.37Weak
lysosomal storage diseaseOpen Targets
0.37Weak
neoplasmOpen Targets
0.10Suggestive
breast cancerOpen Targets
0.09Suggestive
cancerOpen Targets
0.09Suggestive
osteosarcomaOpen Targets
0.06Suggestive
head and neck squamous cell carcinomaOpen Targets
0.06Suggestive
colorectal carcinomaOpen Targets
0.05Suggestive
COVID-19Open Targets
0.04Suggestive
rheumatic diseaseOpen Targets
0.04Suggestive
gastrointestinal stromal tumorOpen Targets
0.03Suggestive
rheumatoid arthritisOpen Targets
0.03Suggestive
lung cancerOpen Targets
0.03Suggestive
kidney cancerOpen Targets
0.02Suggestive
telomere syndromeOpen Targets
0.02Suggestive
lung adenocarcinomaOpen Targets
0.02Suggestive
immune system diseaseOpen Targets
0.02Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
UBCProtein interaction100%SETDB1Protein interaction100%TRIM28Protein interaction98%USP5Protein interaction82%YOD1Protein interaction79%USP44Protein interaction78%
Tissue Expression6 tissues
Heart
100%
Brain
76%
Ovary
48%
Bone Marrow
41%
Lung
38%
Liver
29%
Gene Interaction Network
Click a node to explore
ZNF629UBCSETDB1TRIM28USP5YOD1USP44
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q9UEG4
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.28Highly Constrained
pLIβ“˜
1.00Intolerant
Observed/Expected LoF0.16 [0.10–0.28]
RankingsWhere ZNF629 stands among ~20K protein-coding genes
  • #8,901of 20,598
    Most Researched50
  • #997of 17,882
    Most Constrained (LOEUF)0.28 Β· top 10%
Genes detectedZNF629
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Analysis of copy number variants detected by sequencing in spontaneous abortion.
PMID: 38764094
Mol Cytogenet Β· 2024
1.00