ZNF655 is a zinc finger transcription factor that functions as a regulator of RNA polymerase II-dependent transcription. Structurally, ZNF655 interacts directly with INTS13 within the assembled Integrator complex, serving as a platform for transcription factor recruitment to modulate Integrator stability and regulate transcription attenuation at specific genomic loci 1. ZNF655 demonstrates prominent roles in cell cycle regulation and proliferation control, with mechanisms involving direct transcriptional activation of cell cycle-promoting genes. It binds promoter regions of CDK1 2 and AURKA 3, and regulates expression of PSMB8 4 and other downstream targets. Clinically, ZNF655 is significantly upregulated across multiple malignancies including non-small cell lung cancer 5, hepatocellular carcinoma 4, pancreatic cancer 2, gastric cancer 6, glioma 3, and multiple myeloma 7. Knockdown of ZNF655 consistently suppresses cancer cell proliferation, induces apoptosis, arrests cell cycle at G2, inhibits migration, and reduces tumor formation in xenograft models. ZNF655 activates PI3K/Akt and p53 signaling pathways 5, and recent evidence implicates ZNF655 in disulfidptosis-related pathways in pulmonary hypertension 8. These findings establish ZNF655 as an oncogenic transcription factor with therapeutic potential across diverse cancer types.