ZNF791 is a zinc finger transcription factor involved in transcriptional regulation through RNA polymerase II-specific DNA binding [GO Annotations]. In the context of cardiac pathophysiology, ZNF791 functions as a pro-apoptotic regulator of cardiomyocytes. MicroRNA-488-3p suppresses acute myocardial infarction (AMI)-induced cardiomyocyte apoptosis by directly targeting and downregulating ZNF791 1; overexpression of ZNF791 reverses this protective effect, indicating ZNF791 promotes cardiomyocyte death through caspase-3 activation 1. Similarly, in oxidative stress conditions, ZNF791 mediates hydrogen peroxide-induced cardiomyocyte injury, inflammation, and apoptosis as a downstream target of the KCNQ1OT1/miR-130a-3p regulatory axis 2. These findings establish ZNF791 as a therapeutic target in myocardial infarction. Beyond cardiac disease, ZNF791 exhibits lineage-specific genomic imprinting exclusively in domesticated animals, with maternal methylation at its locus in pigs and cattle, suggesting evolutionary-dependent epigenetic regulation relevant to livestock development 3. The gene's biological significance thus encompasses both transcriptional regulation and disease-specific pro-apoptotic function in cardiomyocytes.