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GeneE
3 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
ZNF92
zinc finger protein 92
Chromosome 7 Β· 7q11.21
NCBI Gene: 168374Ensembl: ENSG00000146757.14HGNC: HGNC:13168UniProt: C9IZS8
27PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingnucleusregulation of DNA-templated transcriptionDNA-binding transcription factor activity, RNA polymerase II-specificovarian neoplasmessential tremorAbruptio Placentaejoint disease
✦AI Summary

Based on limited published evidence, ZNF92 is a zinc finger protein predicted to function as a DNA-binding transcription factor. UniProt annotations indicate it likely regulates transcription through RNA polymerase II-specific binding to cis-regulatory regions and possesses zinc ion binding capability. A heterozygous missense variant in ZNF92, when combined with CLN6 variants, has been associated with bipolar disorder susceptibility in one family study 1. Additionally, ZNF92 expression patterns were altered in hepatocellular carcinoma cells treated with atorvastatin, suggesting potential involvement in statin response 2. However, the precise molecular mechanisms and biological significance of ZNF92 function remain unclear.

Sources cited
1
Heterozygous missense variant in ZNF92 combined with CLN6 variants associated with bipolar disorder phenotype
PMID: 35881528
2
ZNF92 identified as a gene with potential changes in splicing patterns in response to atorvastatin treatment
PMID: 25153832
⚠Limited data available β€” This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
ovarian neoplasmOpen Targets
0.30Weak
essential tremorOpen Targets
0.16Weak
Abruptio PlacentaeOpen Targets
0.16Weak
joint diseaseOpen Targets
0.16Weak
Alzheimer diseaseOpen Targets
0.14Weak
breast cancerOpen Targets
0.05Suggestive
lower urinary tract calculusOpen Targets
0.02Suggestive
neuropathyOpen Targets
0.02Suggestive
optic neuritisOpen Targets
0.02Suggestive
poisoningOpen Targets
0.02Suggestive
cancerOpen Targets
0.02Suggestive
colorectal cancerOpen Targets
0.01Suggestive
neoplasmOpen Targets
0.01Suggestive
pachyonychia congenitaOpen Targets
0.00Suggestive
breast neoplasmOpen Targets
0.00Suggestive
carcinomaOpen Targets
0.00Suggestive
dysplasiaOpen Targets
0.00Suggestive
hyperplasiaOpen Targets
0.00Suggestive
embryonal carcinomaOpen Targets
0.00Suggestive
epilepsyOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
TACSTD2Protein interaction73%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
18%
Heart
12%
Ovary
9%
Liver
7%
Lung
6%
Gene Interaction Network
Click a node to explore
ZNF92TACSTD2
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q03936
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.58LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.99 [0.63–1.58]
RankingsWhere ZNF92 stands among ~20K protein-coding genes
  • #12,720of 20,598
    Most Researched27
  • #15,593of 17,882
    Most Constrained (LOEUF)1.58
Genes detectedZNF92
Sources retrieved3 papers
Response timeβ€”
πŸ“„ Sources
3
1
Heterozygosity for neuronal ceroid lipofuscinosis predisposes to bipolar disorder.
PMID: 35881528
Braz J Psychiatry Β· 2023
1.00
2
Weak evidence for a relation between bipolar disorder and heterozygous ZNF92 and CLN6 variants.
PMID: 36261122
Braz J Psychiatry Β· 2023
0.67
3
RNA-sequencing analysis of HepG2 cells treated with atorvastatin.
PMID: 25153832
PLoS One Β· 2014
0.33