3 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
βGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
27PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETranscription Factor
DATA QUALITYβ Experimental GO Evidenceβ Swiss-Prot Reviewed
protein bindingnucleusregulation of DNA-templated transcriptionDNA-binding transcription factor activity, RNA polymerase II-specificovarian neoplasmessential tremorAbruptio Placentaejoint disease
Based on limited published evidence, ZNF92 is a zinc finger protein predicted to function as a DNA-binding transcription factor. UniProt annotations indicate it likely regulates transcription through RNA polymerase II-specific binding to cis-regulatory regions and possesses zinc ion binding capability. A heterozygous missense variant in ZNF92, when combined with CLN6 variants, has been associated with bipolar disorder susceptibility in one family study 1. Additionally, ZNF92 expression patterns were altered in hepatocellular carcinoma cells treated with atorvastatin, suggesting potential involvement in statin response 2. However, the precise molecular mechanisms and biological significance of ZNF92 function remain unclear.
1
Heterozygous missense variant in ZNF92 combined with CLN6 variants associated with bipolar disorder phenotype
PMID: 358815282
ZNF92 identified as a gene with potential changes in splicing patterns in response to atorvastatin treatment
PMID: 25153832β Limited data available β This gene has 2 indexed publications. Summary and analysis may be incomplete.
ovarian neoplasmOpen Targets
essential tremorOpen Targets
Abruptio PlacentaeOpen Targets
joint diseaseOpen Targets
Alzheimer diseaseOpen Targets
breast cancerOpen Targets
lower urinary tract calculusOpen Targets
optic neuritisOpen Targets
colorectal cancerOpen Targets
pachyonychia congenitaOpen Targets
breast neoplasmOpen Targets
embryonal carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.