ZRANB2 is a nuclear zinc finger protein that functions as a regulator of alternative splicing through RNA binding and interactions with splicing machinery 1. The protein contains two C4 zinc finger motifs that recognize the consensus RNA sequence 5'-AGGUAA-3' 2 and binds to splicing factors U170K, U2AF35, and SFRS17A 1. ZRANB2 localizes to supraspliceosomes and influences splicing of multiple genes including CENTB1, WDR78, CABP4, and SMARCC2 3. Beyond splicing, ZRANB2 suppresses bone morphogenetic protein signaling by interacting with Smad proteins in the nucleus 4. Pathologically, ZRANB2 is upregulated in grade III ovarian carcinoma and regulates splicing programs promoting doxorubicin resistance in breast cancer through ECT2-Ex5 isoform inclusion 5. In glioma, ZRANB2 binds and stabilizes the long non-coding RNA SNHG20, promoting vasculogenic mimicry formation 6. Environmental exposure to arsenite displaces zinc from ZRANB2 zinc fingers, impairing its splicing function and increasing protein expression as a compensatory response 7. These findings establish ZRANB2 as a multifunctional regulatory protein with significant roles in both normal splicing and cancer-associated pathways.