ZSCAN9 is a zinc finger transcription factor containing a conserved SCAN box domain that functions in transcriptional regulation 1. The protein binds sequence-specific double-stranded DNA and regulates transcription through RNA polymerase II-specific mechanisms. ZSCAN9 expression is modulated by genetic variants, with the most significant placental eQTLs affecting ZSCAN9 expression levels, and specific SNPs (including rs1150707) influencing both ZSCAN9 transcription and methylation patterns in regions variably escaping X-chromosome 6 2. Autosomal genetic variation at the ZSCAN9 locus is associated with female-specific changes in X-chromosome 6 and variable escape from X-chromosome 6 3. In disease context, transcriptome-wide association studies identify ZSCAN9 as a potential causal gene in Graves' ophthalmopathy, an autoimmune orbital condition, with suggestive evidence from Mendelian randomization analysis and evidence of shared genetic signals with disease-associated variants 4. These findings suggest ZSCAN9 participates in both normal epigenetic regulation and potentially contributes to autoimmune disease pathogenesis, warranting further investigation into its therapeutic potential.