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GeneE
10 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
ACR
acrosin
Chromosome 22 Β· 22q13.33
NCBI Gene: 49Ensembl: ENSG00000100312.11HGNC: HGNC:126UniProt: P10323
42PubMed Papers
1Diseases
0Drugs
1Pathogenic Variants
FUNCTIONAL ROLE
Protease
CLINICAL
OMIM Disease Gene
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein-containing complexactivation of adenylate cyclase activityserine-type endopeptidase activitynucleusSpermatogenic failure 87
✦AI Summary

Based on the provided abstracts, there is insufficient information to provide a comprehensive summary of ACR (acrosin) gene function. The abstracts primarily discuss unrelated topics using 'ACR' as an abbreviation for different terms: acute cellular rejection in transplantation 12, autophagosomal components recycling 34, systemic immune-inflammation index studies 5, acrylamide toxicity 6, anti-CRISPR proteins 7, and clinical guidelines 8. None of these abstracts contain information about the acrosin gene, its serine protease activity, role in sperm function, or involvement in fertilization processes. The acrylamide study 6 discusses reproductive toxicity but does not address the acrosin gene specifically. To provide an accurate gene function summary for ACR (acrosin), abstracts specifically addressing acrosin protein function, its role in the acrosome reaction, sperm-egg interaction, and male fertility would be required.

Sources cited
1
Discusses acute cellular rejection in lung transplantation, not acrosin gene function
PMID: 38656281
2
Addresses allograft rejection management, not acrosin gene function
PMID: 33938468
3
Studies autophagosomal components recycling, not acrosin gene function
PMID: 38323995
4
Examines mTORC1 regulation of autophagy recycling, not acrosin gene function
PMID: 41237209
5
Investigates acrylamide effects on reproduction but does not address acrosin gene function
PMID: 38874886
6
Focuses on anti-CRISPR genome mining, not acrosin gene function
PMID: 36413017
7
Discusses clinical treatment recommendations, not acrosin gene function
PMID: 39680252
Disease Associationsβ“˜1
Spermatogenic failure 87UniProt
Pathogenic Variants1
NM_001097.3(ACR):c.167G>A (p.Trp56Ter)Pathogenic
Spermatogenic failure 87
β˜†β˜†β˜†β˜†2025β†’ Residue 56
View on ClinVar β†—
Related Genes
ZP2Protein interaction85%IZUMO1Protein interaction78%SPATA16Protein interaction73%TNP1Protein interaction73%SPINK2Protein interaction71%PGPEP1Shared pathway29%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
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ACRZP2IZUMO1SPATA16TNP1SPINK2PGPEP1
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt P10323
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.94LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.63 [0.43–0.94]
RankingsWhere ACR stands among ~20K protein-coding genes
  • #9,825of 20,598
    Most Researched42
  • #5,148of 5,498
    Most Pathogenic Variants1
  • #8,788of 17,882
    Most Constrained (LOEUF)0.94
Genes detectedACR
Sources retrieved10 papers
Response timeβ€”
πŸ“„ Sources
10β–Ό
1
Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study.
PMID: 35386695
Front Immunol Β· 2022
1.00
2
Rab32 family proteins regulate autophagosomal components recycling.
PMID: 38323995
J Cell Biol Β· 2024
0.90
3
Acute rejection post lung transplant.
PMID: 38656281
Curr Opin Pulm Med Β· 2024
0.80
4
Desensitization and management of allograft rejection.
PMID: 33938468
Curr Opin Organ Transplant Β· 2021
0.70
5
mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation.
PMID: 41237209
Proc Natl Acad Sci U S A Β· 2025
0.60