ADAM20 is a membrane-anchored metalloproteinase-disintegrin with a zinc metalloproteinase catalytic domain and conserved disintegrin motif 1. The gene shows testis-specific expression 1 and is predicted to function in sperm maturation and fertilization processes. However, CRISPR/Cas9-generated Adam20-deficient mice exhibited normal fertility, indicating the gene is dispensable for male reproductive function in mice 2. ADAM20 is a predicted target of miR-1183, which is upregulated during cardiac remodeling induced by stretch and tachycardia in human atrial myocardium, with ADAM20 downregulation observed in both acute and chr14 atrial fibrillation settings 3. ADAM20 appears relevant to neurological disease, as CpG-related genetic variants in ADAM20 were associated with Alzheimer's disease risk in Caribbean Hispanic populations at genome-wide significance levels 4. Additionally, ADAM20 was identified among genes with decreased DNA methylation in early-onset high myopia in children, suggesting potential epigenetic involvement in ocular development 5. ADAM20 transcripts were detected at high levels in gastric carcinoma tissue, though H. pylori infection did not increase ADAM20 expression in normal gastric mucosa as observed with other ADAMs 6.