ADAM32 is a membrane-anchored metalloprotease-like protein predominantly expressed in testis 1, with expression beginning during meiotic prophase in pachytene spermatocytes 1. The protein shares high homology with sperm surface proteins ADAM2 and ADAM3 required for fertilization 1, and possesses hyaluronic acid-binding properties potentially involved in sperm-oocyte interactions 2. ADAM32 expression is downregulated following endocrine disruptor exposure, correlating with reduced spermatogenesis and altered intercellular communication in testicular germline cells 3. Beyond its reproductive role, ADAM32 functions as an oncogene in hepatoblastoma (HBL), where it is highly expressed and regulated by the m6A reader protein IGF2BP2 under hypoxic conditions 4. In HBL cells, ADAM32 overexpression increases colony formation, cell migration, invasion, and viability, while promoting cancer stem cell characteristics and epithelial-mesenchymal transition 5. ADAM32 knockdown enhances cisplatin-induced apoptosis through extrinsic caspase-8-dependent pathways 5. ADAM32 alterations, including fusions and amplifications, occur in chromosome 8 rearrangements in various malignancies 67, suggesting broader oncogenic significance. These findings position ADAM32 as a dual-function protein with distinct roles in male reproduction and cancer progression.