2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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14PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
initiator methionyl aminopeptidase activitycysteine-type aminopeptidase activityprotein processingcytoplasminflammatory bowel diseaseovarian dysfunctionmucocutaneous lymph node syndromeDistal myopathy, Nonaka type
Based on limited published evidence, ACTMAP (actin maturation protease) is a cysteine-type aminopeptidase that mediates post-translational maturation of actin. It specifically cleaves N-terminal acetylated methionine from immature cytoplasmic beta- and gamma-actins (ACTB, ACTG1) after translation 1, and cleaves N-terminal acetylated cysteine from muscle alpha-actins (ACTA1, ACTC1, ACTA2) following canonical N-terminal methionine removal. ACTMAP functions as a cysteine protease required for proper actin maturation, with recent studies identifying butynamide-based covalent inhibitors that selectively target its catalytic nucleophile 2.
1
ACTMAP cleaves N-terminal acetylated methionine from immature cytoplasmic beta- and gamma-actins after translation, contributing to actin maturation
PMID: 361738612
ACTMAP is a cysteine protease required for post-translational actin maturation; identified as a selective target of butynamide covalent probes with preferential engagement in cancer cells
PMID: 41757055⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
inflammatory bowel diseaseOpen Targets
ovarian dysfunctionOpen Targets
mucocutaneous lymph node syndromeOpen Targets
Distal myopathy, Nonaka typeOpen Targets
Congenital myasthenic syndromesOpen Targets
myopathy, distal, 5Open Targets
myofibrillar myopathy 3Open Targets
Hereditary proximal myopathy with early respiratory failureOpen Targets
tibial muscular dystrophyOpen Targets
Distal myotilinopathyOpen Targets
Alpha-B crystallin-related late-onset distal myopathyOpen Targets
myopathy, distal, 6, adult-onset, autosomal dominantOpen Targets
myopathy, sarcoplasmic bodyOpen Targets
polyglucosan body myopathy type 2Open Targets
Autosomal dominant limb-girdle muscular dystrophy type 1DOpen Targets
distal myopathy, Welander typeOpen Targets
Autosomal recessive limb-girdle muscular dystrophy due to ISPD deficiencyOpen Targets
distal myopathyOpen Targets
tubular aggregate myopathyOpen Targets
No pathogenic variants reported on ClinVar for this gene.