ADAM11 is a non-catalytic metalloprotease-like protein that functions as a transmembrane disintegrin with key roles in neural development and synaptic function 1. In the nervous system, ADAM11 serves as an essential interacting protein for voltage-gated potassium channel complexes (Kv1.1 and Kv1.2), enabling their localization to cerebellar basket cell terminals where they mediate ephaptic inhibitory synchronization of Purkinje cell firing 2. Beyond its neuronal roles, ADAM11 acts as a non-proteolytic regulator of Wnt and BMP4 signaling pathways during craniofacial development, positively regulating BMP4 signaling while negatively regulating β-catenin activity to control neural crest cell proliferation and migration 34. ADAM11 likely functions as an integrin ligand in the brain 5. Clinically, ADAM11 expression correlates with tumor phenotypes; elevated vitreous ADAM11 levels are associated with proliferative diabetic retinopathy 6, while ADAM11 dysregulation is implicated in cancer development alongside altered Wnt/BMP4 signaling 3. The protein is broadly expressed in brain tissue and maintains relatively consistent expression across glioma grades, distinguishing it from related non-proteolytic ADAMs 7.