ADAP1 — ArfGAP with dual PH domains 1

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

50PubMed Papers

#8,804 · top 45% of 19K genes

20Diseases

top 52%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

GTPase activator activityprotein bindingregulation of GTPase activitycytoplasmCrohn's diseaseasthmahypertensioninflammatory bowel disease

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

ArfGAP with dual PH domains 1

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

Crohn's diseaseOpen Targets

0.45Moderate

asthmaOpen Targets

0.42Moderate

hypertensionOpen Targets

0.40Weak

inflammatory bowel diseaseOpen Targets

0.39Weak

atrial fibrillationOpen Targets

0.32Weak

Intellectual disabilityOpen Targets

0.31Weak

leprosyOpen Targets

0.31Weak

drug allergyOpen Targets

0.31Weak

neurodegenerative diseaseOpen Targets

0.21Weak

Alzheimer diseaseOpen Targets

0.09Suggestive

neoplasmOpen Targets

0.08Suggestive

Abnormality of the skeletal systemOpen Targets

0.06Suggestive

musculoskeletal system diseaseOpen Targets

0.06Suggestive

transient myeloproliferative syndromeOpen Targets

0.05Suggestive

neutropenia, severe congenital, 2, autosomal dominantOpen Targets

0.04Suggestive

squamous cell carcinomaOpen Targets

0.04Suggestive

X-Linked Combined Immunodeficiency DiseasesOpen Targets

0.04Suggestive

agammaglobulinemia 7, autosomal recessiveOpen Targets

0.04Suggestive

immunodeficiency 18Open Targets

0.03Suggestive

immunodeficiency 19Open Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Bone Marrow

81%

Lung

45%

Liver

19%

Ovary

Heart

Gene Interaction Network6 neighbors

Click a node to explore

Structure4 PDB hits

Preparing viewer…

PDB3LJU · 1.70 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.95LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.70 [0.53–0.95]

Rankings2 dim

Where ADAP1 stands among ~20K protein-coding genes

#8,762of 20,598
Most Researched50
#8,879of 17,882
Most Constrained (LOEUF)0.95

Meta

Genes detectedADAP1

Sources retrieved5 papers

Response time—

Sources5

Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells.

PMID: 11869802

Brain Res Mol Brain Res · 2002

0.95

Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.

PMID: 12018390

Eur J Cell Biol · 2002

0.95

Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins.

PMID: 11278595

J Biol Chem · 2001

0.95

Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1.

PMID: 10333475

Biochem J · 1999

0.95

Molecular cloning and functional characterization of a human homologue of centaurin-alpha.

PMID: 10448098

Biochem Biophys Res Commun · 1999

0.95

View all 50 papers on PubMed →

Loading gene record…

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

50PubMed Papers

#8,804 · top 45% of 19K genes

20Diseases

top 52%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

GTPase activator activityprotein bindingregulation of GTPase activitycytoplasmCrohn's diseaseasthmahypertensioninflammatory bowel disease

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

ArfGAP with dual PH domains 1

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

Crohn's diseaseOpen Targets

0.45Moderate

asthmaOpen Targets

0.42Moderate

hypertensionOpen Targets

0.40Weak

inflammatory bowel diseaseOpen Targets

0.39Weak

atrial fibrillationOpen Targets

0.32Weak

Intellectual disabilityOpen Targets

0.31Weak

leprosyOpen Targets

0.31Weak

drug allergyOpen Targets

0.31Weak

neurodegenerative diseaseOpen Targets

0.21Weak

Alzheimer diseaseOpen Targets

0.09Suggestive

neoplasmOpen Targets

0.08Suggestive

Abnormality of the skeletal systemOpen Targets

0.06Suggestive

musculoskeletal system diseaseOpen Targets

0.06Suggestive

transient myeloproliferative syndromeOpen Targets

0.05Suggestive

neutropenia, severe congenital, 2, autosomal dominantOpen Targets

0.04Suggestive

squamous cell carcinomaOpen Targets

0.04Suggestive

X-Linked Combined Immunodeficiency DiseasesOpen Targets

0.04Suggestive

agammaglobulinemia 7, autosomal recessiveOpen Targets

0.04Suggestive

immunodeficiency 18Open Targets

0.03Suggestive

immunodeficiency 19Open Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Bone Marrow

81%

Lung

45%

Liver

19%

Ovary

Heart

Gene Interaction Network6 neighbors

Click a node to explore

Structure4 PDB hits

Preparing viewer…

PDB3LJU · 1.70 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.95LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.70 [0.53–0.95]

Rankings2 dim

Where ADAP1 stands among ~20K protein-coding genes

#8,762of 20,598
Most Researched50
#8,879of 17,882
Most Constrained (LOEUF)0.95