ADAP2 is a GTPase-activating protein that functions as a GAP for Arf6 and binds to phosphatidylinositol phosphates including PI(3,4,5)P3 and PI(3,4)P2 1. The protein serves multiple regulatory roles across different cellular processes. In antiviral immunity, ADAP2 functions as an interferon-stimulated gene that restricts RNA virus entry, including dengue virus and vesicular stomatitis virus, through modulation of Arf6-mediated trafficking and induction of macropinocytosis 1. ADAP2 also acts as a scaffolding protein in RIG-I signaling pathways, bridging mitochondrial MAVS with cytosolic TBK1-IRF3 complexes to facilitate type I interferon production during viral infection 2. In development, ADAP2 plays a critical role in cardiac morphogenesis, with loss-of-function studies in zebrafish demonstrating defects in heart jogging, looping, and valvulogenesis 3. Clinically, elevated ADAP2 expression is associated with aggressive behavior and poor prognosis in clear cell renal cell carcinoma 4, while altered ADAP2 expression in subcutaneous adipose tissue may predict sustained weight loss in metabolic syndrome 5. These diverse functions highlight ADAP2's role in membrane trafficking, immune signaling, and cellular development.