ADIPOR1 (adiponectin receptor 1) is a cell surface receptor that binds to adiponectin, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism 1. Upon adiponectin binding, ADIPOR1 activates downstream signaling cascades involving AMPK phosphorylation and p38 MAPK, leading to increased fatty acid oxidation, enhanced glucose uptake, and decreased gluconeogenesis 1. The receptor exhibits high affinity for globular adiponectin and possesses inherent ceramidase activity, reducing intracellular ceramide levels associated with insulin resistance and inflammation 1. ADIPOR1 signaling is mediated by the adaptor protein APPL1, which binds directly to the receptor's intracellular regions 1. The receptor plays crucial roles in metabolic homeostasis, with therapeutic targeting showing promise in nonalcoholic fatty liver disease through AMPK/SIRT1 pathway activation 2. ADIPOR1 also demonstrates protective effects in diabetic nephropathy by promoting autophagy-mediated lipophagy 3 and exhibits anti-inflammatory properties in atherosclerosis by influencing macrophage polarization toward anti-inflammatory phenotypes 4. Additionally, ADIPOR1 contributes to inflammatory bowel disease regulation through metabolism-dependent mechanisms 5. Dysfunction or reduced expression of ADIPOR1 contributes to adiponectin resistance, a condition associated with obesity, insulin resistance, and metabolic syndrome 6.