ZFP92 — ZFP92 zinc finger protein

6 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

5PubMed Papers

#18,331 · top 94% of 19K genes

20Diseases

top 89%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

RNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription repressor activity, RNA polymerase II-specificnegative regulation of transcription by RNA polymerase IIearly-onset non-syndromic cataractTotal congenital cataractPartial congenital cataractCataract-microcornea syndrome

AI Summary

ZFP92 is a KRAB domain-containing zinc-finger transcription repressor that silences B1/Alu SINE transposable elements and modulates nearby gene transcription in a tissue-specific manner. It regulates glucose homeostasis by modulating MAFB expression in pancreatic islets and lipid metabolism through ACACB regulation in adipose tissue and muscle. Based on limited published evidence, genetic variants in ZFP92 were not associated with premature ovarian insufficiency in a cohort study 1, suggesting this gene may not significantly contribute to ovarian development disorders.

Sources cited

ZFP92 genetic variants were not detected in premature ovarian insufficiency patients, indicating this gene may not significantly contribute to the genetics underlying POI disorders

PMID: 35456418

⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.

Disease Associations20

early-onset non-syndromic cataractOpen Targets

0.11Weak

Total congenital cataractOpen Targets

0.10Suggestive

Partial congenital cataractOpen Targets

0.10Suggestive

Cataract-microcornea syndromeOpen Targets

0.10Suggestive

early-onset nuclear cataractOpen Targets

0.09Suggestive

early-onset zonular cataractOpen Targets

0.09Suggestive

hereditary hyperferritinemia with congenital cataractsOpen Targets

0.08Suggestive

pulverulent cataractOpen Targets

0.08Suggestive

isolated ectopia lentisOpen Targets

0.08Suggestive

Posterior polar cataractOpen Targets

0.08Suggestive

Cataract with Y-shaped suture opacitiesOpen Targets

0.07Suggestive

cataract 35Open Targets

0.07Suggestive

cataract 13 with adult I phenotypeOpen Targets

0.07Suggestive

cataract 38Open Targets

0.07Suggestive

Anterior polar cataractOpen Targets

0.07Suggestive

cataractOpen Targets

0.06Suggestive

Persistent pupillary membraneOpen Targets

0.06Suggestive

Familial ocular anterior segment mesenchymal dysgenesisOpen Targets

0.05Suggestive

Congenital cataract - ichthyosisOpen Targets

0.05Suggestive

congenital cataract-ichthyosis syndromeOpen Targets

0.05Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Bone Marrow

100%

Ovary

59%

Lung

37%

Brain

20%

Liver

11%

Heart

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt A6NM28

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ConstraintgnomAD v4.1

LOEUFⓘ

0.83LoF Tolerant

pLIⓘ

0.65Intermediate

Observed/Expected LoF0.26 [0.11–0.83]

Rankings2 dim

Where ZFP92 stands among ~20K protein-coding genes

#18,510of 20,598
Most Researched5
#7,075of 17,882
Most Constrained (LOEUF)0.83