1 sources retrieved · Most recent: April 2026 · Index updated 16 days ago
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5PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETranscription Factor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
RNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription repressor activity, RNA polymerase II-specificnegative regulation of transcription by RNA polymerase IIearly-onset non-syndromic cataractTotal congenital cataractPartial congenital cataractCataract-microcornea syndrome
ZFP92 is a KRAB domain-containing zinc-finger transcription repressor that silences B1/Alu SINE transposable elements and modulates nearby gene transcription in a tissue-specific manner. It regulates glucose homeostasis by modulating MAFB expression in pancreatic islets and lipid metabolism through ACACB regulation in adipose tissue and muscle. Based on limited published evidence, genetic variants in ZFP92 were not associated with premature ovarian insufficiency in a cohort study 1, suggesting this gene may not significantly contribute to ovarian development disorders.
1
ZFP92 genetic variants were not detected in premature ovarian insufficiency patients, indicating this gene may not significantly contribute to the genetics underlying POI disorders
PMID: 35456418⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
early-onset non-syndromic cataractOpen Targets
Total congenital cataractOpen Targets
Partial congenital cataractOpen Targets
Cataract-microcornea syndromeOpen Targets
early-onset nuclear cataractOpen Targets
early-onset zonular cataractOpen Targets
hereditary hyperferritinemia with congenital cataractsOpen Targets
pulverulent cataractOpen Targets
isolated ectopia lentisOpen Targets
Posterior polar cataractOpen Targets
Cataract with Y-shaped suture opacitiesOpen Targets
cataract 13 with adult I phenotypeOpen Targets
Anterior polar cataractOpen Targets
Persistent pupillary membraneOpen Targets
Familial ocular anterior segment mesenchymal dysgenesisOpen Targets
Congenital cataract - ichthyosisOpen Targets
congenital cataract-ichthyosis syndromeOpen Targets
No pathogenic variants reported on ClinVar for this gene.