1 sources retrieved · Most recent: April 2026 · Index updated 16 days ago
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2PubMed Papers
5Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingnucleoplasmtransposable element silencingtransposable element silencing by piRNA-mediated DNA methylationtype 1 diabetes nephropathybrucellosisCrohn's diseaseulcerative colitis
Based on limited published evidence, C19ORF84 is a protein adapter essential for piRNA-directed transposon methylation during spermatogenesis. It connects the PIWIL4-piRNA pathway to DNA methylation machinery by mediating interactions between SPOCD1 and DNMT3C, facilitating transposon silencing and preventing their mobilization 1. C19ORF84 is required for male fertility and protects germline integrity in both mice and humans through coordinated transposon defense mechanisms 1.
1
C19ORF84 interacts with SPOCD1 and DNMT3C to mediate piRNA-directed DNA methylation of transposons; essential for male mouse fertility and human germ line protection
PMID: 38359823⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
type 1 diabetes nephropathyOpen Targets
Crohn's diseaseOpen Targets
ulcerative colitisOpen Targets
lung adenocarcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.