C1QTNF2 (C1q and TNF related protein 2, also known as CTRP2) is a secreted adipocytokine that functions as a key regulator of lipid metabolism in adipose tissue and liver 1. As a member of the C1q/TNF-related protein family, CTRP2 links metabolic and inflammatory pathways 2. Mechanistically, CTRP2 suppresses triglyceride hydrolysis in adipocytes and inhibits lipolysis through modulation of protein kinase A signaling 1. In vivo studies demonstrate that CTRP2 deficiency increases metabolic rate, enhances adipose tissue lipolysis, and reduces hepatic triglyceride content while elevating plasma triglycerides 1. C1QTNF2 expression is positively correlated with body mass index and is upregulated in obesity 1. Disease relevance includes hepatic fibrosis, where C1QTNF2 expression is reduced during hepatic stellate cell activation and correlates with better clinical outcomes in hepatitis C cirrhosis patients, suggesting a protective role 3. Additionally, C1QTNF2 has been identified as a dysregulated gene in COPD pathogenesis 4 and shows altered expression in inflammatory osteoarthritis 5. Circulating CTRP2 levels are responsive to lipid and insulin stimulation 6, positioning it as a potential therapeutic target for metabolic and fibrotic diseases.