HomeAboutRankingsData Sources
© 2026 GeneE
🧬
GeneE
2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
ADPRM
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
Chromosome 17 · 17p13.1
NCBI Gene: 56985Ensembl: ENSG00000170222.13HGNC: HGNC:30925UniProt: Q3LIE5
8PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
ADP-ribose diphosphatase activityCDP-glycerol diphosphatase activitymanganese ion binding2',3'-cyclic-nucleotide 2'-phosphodiesterase activityIsolated cytochrome C oxidase deficiencyLeigh syndromeleigh syndrome due to mitochondrial complex iv deficiencyParkinson disease 25, autosomal recessive early-onset, with impaired intellectual development
✦AI Summary

Based on limited published evidence, ADPRM is a manganese-dependent phosphohydrolase that hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline, and CDP-ethanolamine. The enzyme contains signature metal-dependent phosphatase domains and is localized to the cytosol 1. ADPRM displays phosphohydrolytic activity on cyclic ADP-ribose and 2',3'-cAMP, with substrate specificity conferred by residues Phe37, Arg43, and Cys253 in the active site region 1. The protein is preferentially expressed in immune cells and may function in immune signaling through ADP-ribose metabolism, which can activate TRPM2 channels as a mediator of oxidative/nitrosative stress.

Sources cited
1
Characterizes human ADPRM phosphohydrolase activity, substrate specificity for ADP-ribose and CDP-alcohols, catalytic mechanism, and key residues (Phe37, Arg43, Cys253) controlling substrate preference and cyclic ADP-ribose hydrolysis
PMID: 25692488
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Isolated cytochrome C oxidase deficiencyOpen Targets
0.15Weak
Leigh syndromeOpen Targets
0.15Weak
leigh syndrome due to mitochondrial complex iv deficiencyOpen Targets
0.15Weak
Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual developmentOpen Targets
0.04Suggestive
attention deficit hyperactivity disorderOpen Targets
0.04Suggestive
hereditary attention deficit-hyperactivity disorderOpen Targets
0.04Suggestive
X-linked intellectual disability - psychosis - macroorchidismOpen Targets
0.03Suggestive
X-linked intellectual disability-psychosis-macroorchidism syndromeOpen Targets
0.03Suggestive
megalencephalic leukoencephalopathy with subcortical cysts 4, remittingOpen Targets
0.03Suggestive
respiratory system diseaseOpen Targets
0.03Suggestive
breast cancerOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
invasive breast ductal carcinomaOpen Targets
0.00Suggestive
acute myeloid leukemiaOpen Targets
0.00Suggestive
cervical cancerOpen Targets
0.00Suggestive
colon adenocarcinomaOpen Targets
0.00Suggestive
colorectal adenocarcinomaOpen Targets
0.00Suggestive
esophageal cancerOpen Targets
0.00Suggestive
gastric cancerOpen Targets
0.00Suggestive
ovarian serous cystadenocarcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
GPAMProtein interaction100%GPAT2Protein interaction98%PRPS1L1Protein interaction93%GPAT4Protein interaction90%GPD1Protein interaction90%GPD2Protein interaction90%
Tissue Expression6 tissues
Ovary
100%
Bone Marrow
94%
Liver
78%
Lung
60%
Brain
42%
Heart
39%
Gene Interaction Network
Click a node to explore
ADPRMGPAMGPAT2PRPS1L1GPAT4GPD1GPD2
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q3LIE5
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.96LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.64 [0.44–0.96]
RankingsWhere ADPRM stands among ~20K protein-coding genes
  • #17,532of 20,598
    Most Researched8
  • #9,045of 17,882
    Most Constrained (LOEUF)0.96
Genes detectedADPRM
Sources retrieved2 papers
Response time—
📄 Sources
2
1
Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase.
PMID: 25692488
PLoS One · 2015
1.00
2
Automatic data processing to achieve a safe telemedical artificial pancreas.
PMID: 20144417
J Diabetes Sci Technol · 2009
0.50