Afamin (AFM) is a serum carrier protein that functions as a transport molecule for hydrophobic substances in body fluids. Its primary role is to solubilize and maintain the activity of lipidated Wnt family members (WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A, and WNT10B), which are essential signaling molecules 1. Additionally, AFM binds and transports vitamin E (α-tocopherol) in the bloodstream 23. Under physiological conditions where the conventional lipoprotein system is insufficient, AFM serves as an alternative transport mechanism for vitamin E 3. Evidence suggests AFM may facilitate vitamin E transport across the blood-brain barrier, potentially protecting neural tissue from oxidative damage 4. By stabilizing these hydrophobic cargo molecules, AFM ensures their bioavailability and biological activity throughout body fluids. The gene is located on chromosome 4 and encodes an extracellular protein involved in nutrient and signaling molecule distribution. While specific disease associations have not been detailed in the provided literature, AFM's critical roles in Wnt signaling and vitamin E homeostasis suggest potential relevance to developmental disorders and oxidative stress-related pathologies.