AGFG2 (ArfGAP with FG repeats 2) is an Arf GTPase-activating protein involved in vesicular trafficking and secretory pathways. As an ArfGAP, AGFG2 mediates GTP hydrolysis of ADP-ribosylation factors (Arfs), which are critical for forming transport intermediates and regulating membrane traffic 1. Unlike the canonical model of ArfGAPs as simple negative regulators, AGFG2 functions actively in cargo sorting and vesicle dynamics 1. Mechanistically, AGFG2 is part of the evolutionarily conserved AGFG family, which emerged in mammals through duplication of AGFG1 and contains a "core module" conserved from invertebrates to humans 2. In endothelial cells, AGFG2 specifically regulates von Willebrand factor (vWF) exocytosis from Weibel-Palade bodies in response to physiological stimuli 1. Disease relevance includes potential involvement in HIV-1 pathogenesis; AGFG2 was identified among disease-specific genes in HIV-1 progression analysis, suggesting a cellular factor role in viral replication 3. The protein localizes to membranes and cytoplasmic compartments, consistent with its role in vesicular transport and potentially in acrosome assembly and spermatid differentiation based on GO annotations. Clinical significance relates to vascular biology and hemostasis through vWF regulation.