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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
GARIN1A
golgi associated RAB2 interactor 1A
Chromosome 7 Β· 7q32.1
NCBI Gene: 346653Ensembl: ENSG00000205085.13HGNC: HGNC:27998UniProt: Q6NXP2
8PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
acrosome assemblyGolgi apparatusseptic shockazoospermiatype 2 diabetes mellitusatrial fibrillation
✦AI Summary

Based on limited published evidence, GARIN1A (golgi associated RAB2 interactor 1A) is a RAB2B effector protein localized to the Golgi apparatus. UniProt annotations indicate its primary function is required for accurate acrosome assembly and normal male fertility. The gene is involved in acrosome formation, a critical process for spermatogenesis. However, no direct functional studies characterizing GARIN1A's molecular mechanisms or role in male infertility have been published in the accessible literature.

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
septic shockOpen Targets
0.11Weak
azoospermiaOpen Targets
0.10Weak
type 2 diabetes mellitusOpen Targets
0.09Suggestive
atrial fibrillationOpen Targets
0.09Suggestive
connective tissue diseaseOpen Targets
0.07Suggestive
corneal ulcerOpen Targets
0.07Suggestive
partial chromosome Y deletionOpen Targets
0.07Suggestive
spermatogenic failure 20Open Targets
0.07Suggestive
spermatogenic failure 72Open Targets
0.06Suggestive
migraine with auraOpen Targets
0.06Suggestive
spermatogenic failure 18Open Targets
0.06Suggestive
spermatogenic failure 27Open Targets
0.06Suggestive
spermatogenic failure 46Open Targets
0.06Suggestive
spermatogenic failure 78Open Targets
0.06Suggestive
spermatogenic failure 42Open Targets
0.06Suggestive
Male infertility due to large-headed multiflagellar polyploid spermatozoaOpen Targets
0.06Suggestive
spermatogenic failure 5Open Targets
0.06Suggestive
spermatogenic failure 86Open Targets
0.06Suggestive
spermatogenic failure, X-linked, 3Open Targets
0.06Suggestive
spermatogenic failure 49Open Targets
0.06Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
SPACA1Shared pathway100%IZUMO3Shared pathway100%AGFG2Shared pathway50%SPINK2Shared pathway50%CHN2Shared pathway50%ZPBPShared pathway50%
Tissue Expression6 tissues
Ovary
100%
Liver
82%
Heart
73%
Lung
60%
Brain
46%
Bone Marrow
45%
Gene Interaction Network
Click a node to explore
GARIN1ASPACA1IZUMO3AGFG2SPINK2CHN2ZPBP
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q6NXP2
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.35LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.94 [0.67–1.35]
RankingsWhere GARIN1A stands among ~20K protein-coding genes
  • #17,602of 20,598
    Most Researched8
  • #14,167of 17,882
    Most Constrained (LOEUF)1.35
Genes detectedGARIN1A
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Predicting metastasized seminoma using gene expression.
PMID: 22243760
BJU Int Β· 2012
1.00