AGTR1 (angiotensin II receptor type 1) is a G protein-coupled receptor that mediates angiotensin II signaling in cardiovascular and renal homeostasis 1. The receptor activates phospholipase C-dependent signaling cascades, regulating blood vessel diameter, calcium mobilization, and inflammatory responses. AGTR1 also participates in the AGTR1-Notch1 axis, which controls cell stemness and chemotherapy responses in acute myeloid leukemia 2. Genetically, AGTR1 polymorphisms significantly influence disease susceptibility. The A1166C polymorphism increases diabetic nephropathy risk, particularly in Asian and Type 2 diabetes populations 3, while rs5186 variants associate with retinopathy of prematurity progression and treatment failure 4. AGTR1 SNPs including rs5186 and rs388915 confer susceptibility to diabetic kidney disease in Type 2 diabetes patients 1. In eclampsia, multiple AGTR1 polymorphisms (rs1799870, rs144520513, rs529360494) correlate with disease onset and alter coagulation and lipid profiles 5. Epigenetic regulation also matters; AGTR1 gene hypomethylation associates with essential hypertension in Chinese farmers 6. Gene-gene interactions between AGTR1 and PPARγ polymorphisms modulate nonalcoholic fatty liver disease risk 7. However, meta-analyses question whether some AGTR1 variants (rs5186) directly predict hypertension susceptibility 8, suggesting complex gene-environment interactions.