GNAQ encodes the G protein subunit alpha q, which functions as a transducer downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades 1. The protein alternates between an active GTP-bound state and an inactive GDP-bound state, with GPCR activation promoting GDP release and GTP binding 1. GNAQ mediates signaling through phospholipase C-beta-dependent inositol lipid hydrolysis, activating PLC-beta to produce diacylglycerol and inositol 1,4,5-trisphosphate 1. The protein plays important roles in vascular endothelial mechanotransduction, where it participates in flow pattern-dependent signaling involving the Piezo1 mechanosensitive channel and P2Y2 receptor 2. Somatic activating mutations in GNAQ are causative for Sturge-Weber syndrome, a neurocutaneous disorder characterized by facial port-wine stains, leptomeningeal angiomatosis, and glaucoma 34. These mutations also cause isolated capillary malformations (port-wine birthmarks) 15. Additionally, GNAQ mutations are found in uveal melanomas and malignant blue melanomas 67. In macrophages, GNAQ mediates SUCNR1 signaling in response to extracellular succinate, regulating transcription of immune function genes 8.