AK7 (adenylate kinase 7) is a nucleoside monophosphate kinase that catalyzes reversible phosphate transfer between nucleoside triphosphates and monophosphates, with highest activity toward AMP [UniProt]. Beyond nucleotide metabolism, AK7 is critically involved in ciliary structure and function through regulation of centriole biogenesis and apical docking 1. AK7 localizes throughout cilia in a DPY30 domain-dependent manner; its depletion reduces cilia number, length, and beat frequency, impairing mucociliary clearance 1. Functionally, AK7 depletion impairs centriole biogenesis and docking, ultimately causing primary ciliary dyskinesia (PCD)-like phenotypes with defective ciliogenesis 1. In male infertility, AK7 mutations cause multiple morphological anomalies of sperm flagella (MMAF) and oligoasthenoteratozoospermia 23. Additionally, AK7 serves as a prognostic indicator in cancers: low AK7 expression in clear cell renal cell carcinoma (ccRCC) correlates with poor outcomes and reduced CD8+ T cell infiltration, while AK7 overexpression enhances anti-PD1 immunotherapy sensitivity 4. Similarly, downregulated AK7 independently predicts poor overall survival in ovarian cancer 5. AK7 also functions as a hub marker in purine metabolism reprogramming associated with dilated cardiomyopathy 6.