AKAP17A (A-kinase anchoring protein 17A) is a multifunctional RNA-binding protein that plays critical roles in mRNA processing and cellular signaling. Its primary function involves regulating alternative splicing and mRNA processing through multiple mechanisms 1. AKAP17A serves as a key component of the SOS splicing system, binding to transposable element (TE)-containing mRNAs and facilitating their excision from host transcripts through interaction with RNA ligase RTCB and bridging protein CAAP1 23. This spliceosome-independent mechanism protects genes from DNA transposon-mediated disruption by recognizing inverted terminal repeat patterns. Additionally, AKAP17A promotes hypoxic adaptation by augmenting HIF1α protein synthesis through a PKA-independent pathway, supporting tumor growth and cellular oxygen homeostasis 4. The protein also interacts with CAAP1 in mRNA splicing pathways, influencing platinum sensitivity in ovarian cancer 5. AKAP17A expression levels are associated with aging phenotypes, particularly cognitive decline and physical ability deterioration 1. In sex chromosome X|Y, AKAP17A shows altered expression patterns that correlate with X chromosome X|Y, suggesting its involvement in epigenetic regulation 67. Clinical significance includes potential biomarker applications in cancer drug resistance and aging-related cognitive decline.