ANK2 (ankyrin 2) is a critical membrane scaffolding protein that stabilizes ion transporters and channels in multiple cell types, particularly in cardiac and neuronal tissues. In cardiomyocytes, ANK2 coordinates the assembly of key proteins including Na/Ca exchangers, Na/K ATPases, and calcium channels at specialized membrane sites 1. The protein plays essential roles in neuronal function, where loss-of-function variants cause neurodevelopmental disorders characterized by autism spectrum disorders, epilepsy, and intellectual disability 23. ANK2-deficient neurons exhibit hyperactive and desynchronized network activity with impaired axon initial segment plasticity, contributing to the neurological phenotypes observed in patients 2. In cardiac contexts, ANK2 variants have been associated with hypertrophic cardiomyopathy, where patients show increased wall thickness, though its classification as a definitive long QT syndrome gene remains disputed with only limited evidence supporting this association 14. ANK2 also participates in cellular processes beyond ion channel regulation, including endocytosis and protein trafficking through interactions with the cytoskeleton 5. The protein's dysfunction appears to converge with other autism-associated genes in neuronal networks, highlighting its importance in neurodevelopmental pathways.