ANKRD23 is a member of the muscle ankyrin repeat protein (MARP) family that functions as a stress-responsive protein in cardiac and skeletal muscle. The protein contains ankyrin repeats that enable binding to the N2A region of titin, localizing it to sarcomeric structures 1. ANKRD23 demonstrates mechanosensitive properties, with mRNA levels increasing 19-fold in gastrocnemius muscle following sprint interval training and 14-fold when intraluminal pressure is increased in cannulated arteries 2. The protein appears to function as a molecular transducer between mechanical stress and transcriptional responses, as it can shuttle to the nucleus where it may regulate gene expression 1. ANKRD23 expression is upregulated under various pathological conditions, including IL11-induced cardiac dysfunction where it is expressed alongside other stress factors in cardiomyocytes 3, and in anthracycline-induced cardiotoxicity 4. Additionally, ANKRD23 is downregulated in right ventricular outflow tract tissue from patients with ventricular arrhythmias 5 and upregulated in tongue cancer associated with early metastasis 6. These findings suggest ANKRD23 serves as both a mechanosensor and stress response marker in muscle tissues, with potential roles in cardiovascular pathophysiology and cancer progression.