ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) is a PTB adapter protein that regulates receptor tyrosine kinase trafficking and signaling. Functionally, ANKS1A localizes to the endoplasmic reticulum (ER) where its ankyrin repeat domain binds receptor tyrosine kinases (RTKs) including EphA2 and EGFR, while its PTB domain interacts with Sec23 1. This dual binding facilitates COPII-mediated anterograde transport of RTKs from the ER to the cell surface 12. Additionally, ANKS1A regulates EGFR recycling from endosomes back to the plasma membrane, with ANKS1A knockdown promoting lysosomal degradation 3. Beyond RTK trafficking, ANKS1A mediates LRP1-dependent amyloid-beta clearance across the blood-brain barrier by facilitating LRP1 surface expression, with ANKS1A deficiency exacerbating Alzheimer's disease pathology in mice 4. Clinically, ANKS1A dysfunction associates with multiple diseases: genetic variants are linked to coronary artery disease risk, particularly in type 1 diabetes patients and familial hypercholesterolemia 56, while aberrant ANKS1A expression promotes breast cancer cell migration through ErbB2 signaling 7.